项目: 1、 国家自然科学基金委员会, 面上项目, 81872983, 酸浆属清热解毒中药抗肿瘤睡茄内酯的发现及其作用靶点研究, 2019-01-01 至 2022-12-31, 57万元, 资助期满, 参与。 2、 江苏省科研创新计划，KYCX21_0683，Tubocapsenolide A (TA) 抗骨肉瘤作用机制与靶点研究，2021-06-04至2022-06-04，1.5万，主持。 论文: 1、Dongrong Zhu, Shang Li, Chen Chen, Sibei Wang, Jiangmin Zhu, Lingyi Kong*, Jianguang Luo*. Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect. Pharmacological Research, 2021;166:105523. 2、 Dongrong Zhu#, Yuanzheng Xia#, Shang Li, Min Kong, Chen Chen, Guimin Xue, Lingyi Kong*, Jianguang Luo*. Iso-seco-tanapartholide activates Nrf2 signaling pathway through Keap1 modification and oligomerization to exert anti-inflammatory effects. Free Radical Biology and Medicine, 2022;178:398-412. 3、 Dongrong Zhu#, Chen Chen#, Xiaoqin Liu, Sibei Wang, Jiangmin Zhu, Hao Zhang, Lingyi Kong*, Jianguang Luo*. Osteosarcoma cell proliferation suppression via SHP-2-mediated inactivation of the JAK/STAT3 pathway by Tubocapsenolide A. Journal of Advanced Research, 2021; 34:79–91. 4、 Dongrong Zhu, Min Kong, Chen Chen, Jianguang Luo*, Lingyi Kong*. Iso-seco-tanapartholide induces p62 covalent oligomerization to activate KEAP1-NRF2 redox pathway in rheumatoid arthritis. International Immunopharmacology, 2023;115:109689. 5、 Dongrong Zhu, Chen Chen, Yuanzheng Xia, Ling-Yi Kong*, Jianguang Luo* A Purified Resin Glycoside Fraction from Pharbitidis Semen Induces Paraptosis by Activating Chloride Intracellular Channel-1 in Human Colon Cancer Cells. Integrative Cancer Therapies, 2019;18:1534735418822120. 6、 Dongrong Zhu, Chen Chen, Lijuan Bai, Lingyi Kong*, and Jianguang Luo*. Downregulation of Aquaporin 3 Mediated the Laxative Effect in the Rat Colon by a Purified Resin Glycoside Fraction from Pharbitis Semen. Evidence Based Complementary and Alternative Medicine. 2019; 2019:1-10. 7、Feiyan Liu#, Dongrong Zhu#, Yin Li, Lingyi Kong*, Jianguang Luo*. A multifunctional near-infrared fluorescent probe for in vitro and in vivo imaging of γ-glutamyltranspeptidase and photodynamic cancer therapy. Sensors and Actuators B: Chemical, 2022; 363:131838. 获奖: 研究生国家奖学金 （2022年度），第一 |
